A simple,economical, and environmentally benign protocol for the synthesis of 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines at ambient temperature |
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| Authors: | Uday V. Desai Makarand A. Kulkarni Kapil S. Pandit Aparna M. Kulkarni Prakash P. Wadgaonkar |
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| Affiliation: | 1. Organic Chemistry Division, Department of Chemistry, Shivaji University, Kolhapur, India;2. Polymer Science and Engineering Division, CSIR, National Chemical Laboratory, Pune, India |
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| Abstract: | ![]()
A simple, economical, and environmentally benign protocol has been described for one-pot synthesis of medicinally privileged 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines by three-component condensation between aldehyde, malononitrile, and thiol using diethylamine as a catalyst. Ambient temperature and avoidance of conventional work-up as well as purification procedure qualify this cost-effective protocol for “green synthesis.” |
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| Keywords: | multicomponent reactions diethylamine pyridine-3,5-dicarbonitriles organocatalyst green chemistry |
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