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Design and synthesis of new imidazo[1,2-b]pyrazole derivatives,in vitro α-glucosidase inhibition,kinetic and docking studies |
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| Authors: | Peytam Fariba Adib Mehdi Shourgeshty Reihaneh Mohammadi-Khanaposhtani Maryam Jahani Mehdi Imanparast Somaye Faramarzi Mohammad Ali Mahdavi Mohammad Moghadamnia Ali Akbar Rastegar Hossein Larijani Bagher |
| Institution: | 1.School of Chemistry, College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran ;2.Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran ;3.Department of Pharmaceutical Biotechnology, Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran ;4.Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran ;5.Department of Pharmacology, Faculty of Medical Sciences, Babol University of Medical Sciences, Babol, Iran ;6.Food and Drug Research Institute, Food and Drug Administration, MOHE, Tehran, Iran ; |
| Abstract: | Molecular Diversity - A new series of imidazo1,2-b]pyrazole derivatives 4a–o was designed, synthesized, and screened for in vitro α-glucosidase inhibitory activity. All compounds showed... |
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