Stereoselective synthesis of individual isomers of Leu-enkephalin analogues containing substituted beta-turn bicyclic dipeptide mimetics |
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| Authors: | Xiong Chiyi Zhang Junyi Davis Peg Wang Wei Ying Jinfa Porreca Frank Hruby Victor J |
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| Institution: | Department of Chemistry, University of Arizona, 1306 E. University Blvd., Tucson, AZ 85721, USA. |
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| Abstract: | Novel constrained beta-turn dipeptide mimetics, 8-phenyl thiaindolizidinone amino acids 3, have been synthesized stereoselectively and incorporated into Leu-enkephalin peptides as a replacement of dipeptide Gly3-Phe4 to afford four individual isomers of Leu-enkephalin analogues 6. |
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