| 液相色谱串联质谱同位素稀释法对蜂王浆中10种硝基咪唑类药物残留的检测 |
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| 引用本文： | 谢文,陈笑梅,丁慧瑛,侯建波,奚君阳,钱艳.液相色谱串联质谱同位素稀释法对蜂王浆中10种硝基咪唑类药物残留的检测[J].分析测试学报,2010,29(5). |
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| 作者姓名： | 谢文 陈笑梅 丁慧瑛 侯建波 奚君阳 钱艳 |
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| 作者单位： | 1. 浙江出入境检验检疫局技术中心,浙江,杭州,310012
2. 浙江立德产品技术有限公司,浙江,杭州,310012 |
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| 基金项目： | 浙江省科技厅资助项目 |
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| 摘 要： | 建立了液相色谱-电喷雾串联质谱法(LC-ESIMS/MS)测定蜂王浆中10种硝基咪唑类药物残留的分析方法。蜂王浆样品经甲醇沉淀蛋白质,弱碱性条件下乙酸乙酯提取硝基咪唑类药物残留,Oasis(HLB)和C18固相萃取柱净化后,通过液相色谱-质谱联用技术进行检测(正离子方式,多反应监测模式),采用同位素稀释内标法或外标法进行定量。方法的线性范围为5.0~60μg/kg,相关系数大于0.999,在10、20、50μg/kg加标水平的回收率为70%~105%,相对标准偏差小于12.7%,定量下限均为10μg/kg。该方法定量准确,适用于对蜂王浆中硝基咪唑类药物残留的确证检测。
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| 关 键 词： | 蜂王浆 液相色谱-串联质谱法 硝基咪唑类药物残留 |
Determination of Ten Nitroimidazole Residues in Royal Jelly by High Performance Liquid Chromatography Tandem Mass Spectrometry |
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| XIE Wen,CHEN Xiao-mei,DING Hui-ying,HOU Jian-bo,XI Jun-yang,QIAN Yan.Determination of Ten Nitroimidazole Residues in Royal Jelly by High Performance Liquid Chromatography Tandem Mass Spectrometry[J].Journal of Instrumental Analysis,2010,29(5). |
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| Authors: | XIE Wen CHEN Xiao-mei DING Hui-ying HOU Jian-bo XI Jun-yang QIAN Yan |
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| Institution: | XIE Wen1,CHEN Xiao-mei1,DING Hui-ying1,HOU Jian-bo1,XI Jun-yang2,QIAN Yan2(1.Zhejiang Entry-Exit Inspection and Quarantine Bureau,Hangzhou 310012,China,2.Zhejiang Lead Product Technic Co.Ltd.,China) |
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| Abstract: | Nitroimidazoles and their hydroxy metabolites are banned substances with antibiotic and anticoccidial activity.They are suspected to be carcinogenic and mutagenic.In this paper,a rapid,sensitive and selective method for the determination of ten nitroimidazole residues,including dimetridazole(DMZ),2-hydroxymethyl-1-methyl-5-nitroimidazole(HMMNI) or dimetridazole-OH(DMZOH),metronidazole(MNZ),metronidazole-OH(MNZOH),ronidazole(RNZ),5-nitrobenzimidazole(NBI),ipronidazole(IPZ),ipronidazole-OH(IPZOH),2-methyl-5-n... |
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| Keywords: | royal jelly high performance liquid chromatography tandem mass spectrometry nitroimidazole residues |
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