CuI/TMEDA催化合成芳基葡萄糖碳苷化合物

以THF为溶剂， CuI/TMEDA为催化剂，四乙酰溴代葡萄糖与芳基溴化镁经取代反应合成了芳基葡萄糖碳苷（2a~2c），其结构经¹H NMR和¹³C NMR确证。该方法立体选择性较好。在最佳反应条件(THF为溶剂，10% CuI和10% TMEDA为催化剂，于0 ℃反应至终点)下，2a~2c的收率为58%~71%， α/β为1/6.5~1/7.1。

Synthesis of C-aryl Glycosides Catalyzed by CuI/TMEDA

C-aryl glycosides(2a~2c) were stereoselectively synthesized by substitution reaction of 2, 3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide and aryl Grignard reagents, using THF as the solvent and CuI/TMEDA as the catalyst.The structures were confirmed by 1 H NMR and 13 C NMR.Under the optimized reaction conditions(THF as the solvent, 10%CuI and 10%TMEDA as the catalyst, and the reac-tion temperature was 0℃), the yields of 2a~2c were 58%~71%andα/βwere 1/6.5~1/7.1.