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Structural optimization of adaptaquin,a HIF prolyl hydroxylase inhibitor |
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| Authors: | Poloznikov A A Khristichenko A Yu Smirnova N A Hushpulian D M Gaisina I N Osipyants A I Tishkov V I Gazaryan I G |
| Institution: | 1.Dmitry Rogachev National Medical Research Center for Pediatric Hematology, Oncology, and Immunology, 1 ul. Samory Mashela, 117997, Moscow, Russian Federation ;2.National Medical Research Radiological Center, Ministry of Health of the Russian Federation, 4 ul. Koroleva, 249036, Obninsk, Russian Federation ;3.Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood, Chicago, IL, 60612, USA ;4.Department of Chemistry, M. V. Lomonosov Moscow State University, Build 3, 1 Leninskie Gory, 119991, Moscow, Russian Federation ;5.Innovations and High Technologies MSU Ltd., 16 ul. Tsymlyanskaya, 109451, Moscow, Russian Federation ;6.A. N. Bach Institute of Biochemistry, Russian Academy of Sciences, Federal Research Center “Fundamentals of Biotechnology”, Build. 2, 33 Leninsky prosp., 119071, Moscow, Russian Federation ; |
| Abstract: | Russian Chemical Bulletin - The structural optimization of adaptaquin, viz., 7-(4-chlorophenyl)(3-hydroxypyridin-2-yl)amino]methylquinolin-8-ol, a HIF (hypoxia inducible factor) prolyl hydroxylase... |
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