| 2,3-二甲基-4-氯吡啶-N-氧化物的合成工艺改进 |
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| 引用本文： | 冯晓亮,吕延文,吾国强.2,3-二甲基-4-氯吡啶-N-氧化物的合成工艺改进[J].合成化学,2006,14(6):637-639. |
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| 作者姓名： | 冯晓亮 吕延文 吾国强 |
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| 作者单位： | 浙江工业大学,浙西分校,化学与制药工程系,浙江,衢州,324000 |
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| 摘 要： | 对2,3-二甲基-4-氯吡啶-N-氧化物(4)的合成工艺进行了改进。以2,3-二甲基吡啶为原料,经氧化(钨酸钠为催化剂,双氧水为氧化剂,收率96.5%),硝化(65%的浓硝酸为硝化剂,收率86.3%,纯度99.0%)及氯化(乙酰氯为氯化剂,收率86.8%,纯度98.6%)合成了4,总收率72.2%,4的结构经1H NMR表征。
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| 关 键 词： | 甲基吡啶 N-氧化物 合成 工艺改进 |
| 文章编号： | 1005-1511（2006）06-0637-03 |
| 收稿时间： | 2006-05-12 |
| 修稿时间： | 2006年5月12日 |
Process Improvement on the Synthesis of 4-Chloro-2,3-dimethylpyridine-N-oxide |
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| FENG Xiao-liang,L Yan-wen,WU Guo-qiang.Process Improvement on the Synthesis of 4-Chloro-2,3-dimethylpyridine-N-oxide[J].Chinese Journal of Synthetic Chemistry,2006,14(6):637-639. |
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| Authors: | FENG Xiao-liang L Yan-wen WU Guo-qiang |
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| Institution: | Department of Chemical and Medical Engineering, West Branch of Zhejiang University of Technology, Quzhou 324000, China |
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| Abstract: | 4-Chloro-2,3-dimethylpyridineN-oxide(4) were synthesized from 2,3-dimethylpyridine by the reaction of oxidation(sodium tungstate as a catalyst,hydrogen peroxide as a oxidant,yield of(96.5%)),nitration(65% nitric acid as a nitrating agent,yield of 86.3%,purity of 99.0%) and chlorination(acetyl chloride as a chloridizing agent,yield of 86.8%,purity of 98.6%).The overall yield reached 72.2%.The structure of 4 was identified by ~1H NMR. |
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| Keywords: | methylpyridine Noxide synthesis process improvement |
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