| A likelihood-based method for haplotype association studies of case-control data with genotyping uncertainty |
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| 引用本文： | ZHU Wensheng & GUO Jianhua School of Mathematics and Statistics,Northeast Normal University,Changchun 130024,China. A likelihood-based method for haplotype association studies of case-control data with genotyping uncertainty[J]. 中国科学A辑(英文版), 2006, 49(1): 130-144. DOI: 10.1007/s11425-005-0147-5 |
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| 作者姓名： | ZHU Wensheng & GUO Jianhua School of Mathematics and Statistics Northeast Normal University Changchun 130024 China |
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| 作者单位： | ZHU Wensheng & GUO Jianhua School of Mathematics and Statistics，Northeast Normal University，Changchun 130024，China |
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| 摘 要： | This paper discusses the associations between traits and haplotypes based on Fl (fluorescent intensity) data sets. We consider a clustering algorithm based on mixtures of t distributions to obtain all possible genotypes of each individual (i.e. "GenoSpec-trum"). We then propose a likelihood-based approach that incorporates the genotyping uncertainty to assessing the associations between traits and haplotypes through a haplotype-based logistic regression model. Simulation studies show that our likelihood-based method can reduce the impact induced by genotyping errors.
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| 收稿时间： | 2005-05-12 |
| 修稿时间： | 2005-08-14 |
A likelihood-based method for haplotype association studies of case-control data with genotyping uncertainty |
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| ZHU Wensheng,GUO Jianhua. A likelihood-based method for haplotype association studies of case-control data with genotyping uncertainty[J]. Science in China(Mathematics), 2006, 49(1): 130-144. DOI: 10.1007/s11425-005-0147-5 |
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| Authors: | ZHU Wensheng GUO Jianhua |
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| Affiliation: | School of Mathematics and Statistics, Northeast Normal University, Changchun 130024, China |
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| Abstract: | This paper discusses the associations between traits and haplotypes based on Fl (fluorescent intensity) data sets. We consider a clustering algorithm based on mixtures of t distributions to obtain all possible genotypes of each individual (i.e. "GenoSpec-trum"). We then propose a likelihood-based approach that incorporates the genotyping uncertainty to assessing the associations between traits and haplotypes through a haplotype-based logistic regression model. Simulation studies show that our likelihood-based method can reduce the impact induced by genotyping errors. |
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| Keywords: | haplotype-based association GenoSpectrum case-control study genotyping error logistic regression |
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