| A likelihood-based method for haplotype association studies of case-control data with genotyping uncertainty |
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| 作者姓名： | ZHU Wensheng & GUO Jianhua School of Mathematics and Statistics Northeast Normal University Changchun China |
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| 作者单位： | ZHU Wensheng & GUO Jianhua School of Mathematics and Statistics，Northeast Normal University，Changchun 130024，China |
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| 摘 要： | This paper discusses the associations between traits and haplotypes based on Fl (fluorescent intensity) data sets. We consider a clustering algorithm based on mixtures of t distributions to obtain all possible genotypes of each individual (i.e. "GenoSpec-trum"). We then propose a likelihood-based approach that incorporates the genotyping uncertainty to assessing the associations between traits and haplotypes through a haplotype-based logistic regression model. Simulation studies show that our likelihood-based method can reduce the impact induced by genotyping errors.
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| 收稿时间： | 12 May 2005 |
| 修稿时间： | 14 August 2005 |
A likelihood-based method for haplotype association studies of case-control data with genotyping uncertainty |
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| ZHU Wensheng & GUO Jianhua School of Mathematics and Statistics,Northeast Normal University,Changchun ,China.A likelihood-based method for haplotype association studies of case-control data with genotyping uncertainty[J].Science in China(Mathematics),2006,49(1):130-144. |
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| Authors: | ZHU Wensheng GUO Jianhua |
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| Institution: | School of Mathematics and Statistics, Northeast Normal University, Changchun 130024, China |
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| Abstract: | This paper discusses the associations between traits and haplotypes based on Fl (fluorescent intensity) data sets. We consider a clustering algorithm based on mixtures of t distributions to obtain all possible genotypes of each individual (i.e. "GenoSpec-trum"). We then propose a likelihood-based approach that incorporates the genotyping uncertainty to assessing the associations between traits and haplotypes through a haplotype-based logistic regression model. Simulation studies show that our likelihood-based method can reduce the impact induced by genotyping errors. |
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| Keywords: | haplotype-based association GenoSpectrum case-control study genotyping error logistic regression |
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