Synthesis of mangiferin derivatives as protein tyrosine phosphatase 1B inhibitors |
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| Authors: | Hong-gang Hu Ming-juan Wang Qing-jie Zhao Hong-li Liao Ling-zhi Cai Yan Song Jun Zhang Shi-chong Yu Wan-sheng Chen Chao-mei Liu Qiu-ye Wu |
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| Institution: | (1) Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433, People’s Republic of China;(2) Department of Pharmacy, Chang Zheng Hospital, Second Military Medical University, People’s Republic of China |
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| Abstract: | Protein tyrosine phosphatase 1B (PTP1B) has received much attention due to its pivotal role in type 2 diabetes and obesity
as a negative regulator of the insulin signaling pathway. Mangiferin, a xanthone glucoside, has been reported to possess significant
antidiabetic activity. In the present study, a series of mangiferin derivatives was synthesized and evaluated for their PTP1B
inhibitory activity. Some of the screened compounds displayed good PTP1B inhibitory activity.
Published in Khimiya Prirodnykh Soedinenii, No. 6, pp. 549–551, November–December, 2007. |
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| Keywords: | mangiferin protein tyrosine phosphatase 1B derivatives inhibition |
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