One‐Pot Synthesis of 1,4‐Oxathiino[2,3‐b]quinoxalines or ‐pyrazines from 2,3‐Dichloroquinoxaline or ‐pyrazine and 1‐Aryl‐2‐bromoalkan‐1‐ones |
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| Authors: | Kazuhiro Kobayashi Natsuki Konishi Teruhiko Suzuki Kazuhiro Nakagawa |
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| Institution: | Division of Applied Chemistry, Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4‐101 Koyama‐minami, Tottori 680‐8552, Japan, (phone/fax +81‐857‐315263) |
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| Abstract: | An efficient one‐pot synthesis of novel heterocyclic derivatives, 2‐aryl‐1,4‐oxathiino2,3‐b]quinoxalines or ‐pyrazines 5 , via the reaction of 2,3‐dichloroquinoxaline or ‐pyrazine with Na2S?9 H2O, and subsequent treatment of the resulting 2‐chloro‐3‐sodiosulfanylquinoxaline or ‐pyrazine 2 with 1‐aryl‐2‐bromo‐1‐alkanones and then NaH under mild conditions is described. |
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| Keywords: | 1 4‐Oxathiino[2 3‐b]quinoxalines 1 4‐Oxathiino[2 3‐b]pyrazines Quinoxaline 2 3‐dichloro‐ Pyrazine 2 3‐dichloro‐ Sodium sulfide nonahydrate |
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