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One‐Pot Synthesis of Sulfonamides and Sulfonyl Azides from Thiols using Chloramine‐T |
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| Authors: | Behrooz Maleki Saba Hemmati Reza Tayebee Sirous Salemi Yasaman Farokhzad Mehdi Baghayeri Farrokhzad Mohammadi Zonoz Elahe Akbarzadeh Rohollah Moradi Azam Entezari Mohammad Reza Abdi Samaneh Sedigh Ashrafi Fereshteh Taimazi Majid Hashemi |
| Institution: | 1. Hakim Sabzevari University, Department of Chemistry, Sabzevar 96179‐76487, Iran, (phone: +985714410104;2. fax: +9857144111161);3. Young Researchers and Elite Club, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran;4. Payame Noor University (PNU), Department of Chemistry, Tehran 19395‐4697, Iran;5. Kharazmi University, Department of Chemistry, Shahid Mofatteh Ave. No. 43, Tehran, Iran;6. Center for Research and Development of Petroleum Technologies at Kermanshah, Kermanshah, Iran |
| Abstract: | A convenient synthesis of sulfonamides and sulfonyl azides from thiols is described. In situ preparation of sulfonyl chlorides from thiols was accomplished by oxidation with chloramine‐T (=N‐chlorotosylamide=N‐chloro‐4‐methylbenzenesulfonamide), tetrabutylammonium chloride (Bu4NCl), and H2O. The sulfonyl chlorides were then further allowed to react with excess amine or NaN3 in the same pot. |
| Keywords: | Sulfonamides Sulfonyl azides Thiols Chloramine‐T Multicomponent reactions |