Two New Abietane Diterpenoids from the Roots of Tripterygium wilfordii Hook. f. |
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| Authors: | Jian‐You Li Ying Peng Ling‐Zhi Li Pin‐Yi Gao Chang Gao Su‐Xia Xia Shao‐Jiang Song |
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| Institution: | 1. School of Traditional Chinese Materia Medica, Key Laboratory of Structure‐Based Drug Design & Discovery, Shenyang Pharmaceutical University, Ministry of Education, Shenyang 110016, Liaoning, P.?R. China (phone/fax: +86‐24‐23986510);2. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, P.?R. China;3. College of Chemical Engineering, Shenyang University of Chemical Technology, Shenyang 110142, Liaoning, P.?R. China;4. Laboratory of Clinical Pharmacology, Academy of Traditional Chinese Medicine of Liaoning Province, Shenyang 110034, Liaoning, P.?R. China |
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| Abstract: | Two new abietane‐type diterpenoids, named triptobenzene R ( 1 ) and triptobenzene S ( 2 ), together with three known abietane‐type diterpenoids, triptophenolide ( 3 ), triptonodiol ( 4 ), and triptonoterpene methyl ether ( 5 ), were isolated from the roots of Tripterygium wilfordii Hook . f. Their structures and relative configurations were established by detailed spectral studies, including 1D‐ and 2D‐NMR (HSQC, HMBC, and NOESY), and HR‐ESI‐TOF‐MS, and by comparison with published data. Their absolute configurations were assigned by the CD technique, applied for the first time to abietane diterpenes from Tripterygium wilfordii. Compound 2 is the first abietane‐type norditerpenoid isolated from the genus Tripterygium. |
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| Keywords: | Tripterygium wilfordii Triptobenzenes R and S Abietanes Norditerpenoids |
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