Four New Alkaloids from the Fermentation Broth of Armillaria mellea |
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| Authors: | Yun‐Chao Wang Yu‐Wei Zhang Li‐Hua Zheng Yong‐Li Bao Yin Wu Chun‐Lei Yu Yan‐Xin Huang Lu‐Guo Sun Yu Zhang Xiu‐Juan Jia Yu‐Xin Li |
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| Institution: | 1. School of Life Sciences, Northeast Normal University, Renmin Street 5268, Changchun 130024, P.?R. China;2. Institute of Genetics and Cytology, Northeast Normal University, Renmin Street 5268, Changchun 130024, P.?R. China (phone/fax: +86‐431‐85099520);3. National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Renmin Street 5268, Changchun 130024, P.?R. China;4. Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education, Northeast Normal University, Renmin Street 5268, Changchun 130024, P.?R. China |
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| Abstract: | Four compounds with similar structures and UV spectra were isolated from the fermentation broth of Armillaria mellea by means of preparative HPLC. Their structures were established as methyl (2S)‐1‐2‐(furan‐2‐yl)‐2‐oxoethyl]‐5‐oxopyrrolidine‐2‐carboxylate ( 1 ), (2S)‐1‐2‐(furan‐2‐yl)‐2‐oxoethyl]‐5‐oxopyrrolidine‐2‐carboxylic acid ( 2 ), 1‐2‐(furan‐2‐yl)‐2‐oxoethyl]pyrrolidin‐2‐one ( 3 ) and 1‐2‐(furan‐2‐yl)‐2‐oxoethyl]piperidin‐2‐one ( 4 ) on the basis of their 1D‐ and 2D‐NMR, and HR‐MS data. The absolute configurations of compounds 1 and 2 were determined by comparison of the experimental and calculated electronic circular dichroism (ECD) data. Additionally, four known compounds, 5 – 8 , were also isolated. |
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| Keywords: | Armillaria mellea Pyrrolidines Fermentation Electronic circular dichroism (ECD) Density‐functional theory (DFT) |
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