New Cytotoxic Metabolites from the Marine‐Derived Fungus Penicillium sp. ZLN29

One new penicillide derivative, prenpenicillide ( 1 ), and one new xanthone derivative, prenxanthone ( 2 ), were isolated from the culture extract of the marine‐derived fungus Penicillium sp. ZLN29, together with six known polyketide compounds, 3 – 8 . Their structures were elucidated on the basis of spectroscopic and spectrometric analyses. The cytotoxicities of these eight compounds were evaluated on four tumor‐cell lines by SRB (=sulforhodamine B) or MTT (=3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) methods. Compounds 1 and 3 exhibited weak cytotoxicities against HepG2 cell line with IC₅₀ values of 9.9 and 9.7 μM , respectively.