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Electrochemical Oxidation of Ibuprofen and Its Voltammetric Determination at a Boron‐Doped Diamond Electrode |
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| Authors: | Amanda B. Lima Eric O. Faria Rodrigo H. O. Montes Rafael R. Cunha Eduardo M. Richter Rodrigo A. A. Munoz Wallans T. P. dos Santos |
| Affiliation: | 1. Departamento de Química, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Rod MGT 367 – Km 583, Diamantina, MG, Brazil;2. Departamento de Farmácia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Rod MGT 367 – Km 583, Diamantina, MG, Brazil;3. Instituto de Química, Universidade Federal de Uberlandia, Av. Jo?o Naves de ávila, 2121, Uberlandia, MG, Brazil. tel: 55‐34‐3239‐4143;4. fax: 55‐34‐3239‐4208 |
| Abstract: | The electrochemical oxidation of ibuprofen at a boron‐doped diamond electrode (BDDE) and its voltammetric determination is reported for the first time. A well‐defined oxidation peak was observed at around 1.6 V in 0.1 mol L?1 H2SO4 solution with 10 % (v/v) ethanol at the BDDE surface activated by either cathodic or anodic pretreatments. A differential‐pulse voltammetric method for the determination of ibuprofen in pharmaceutical formulations was optimized with a detection limit of 5 µmol L?1 and compared with the British Pharmacopeia method. |
| Keywords: | Ibuprofen Boron‐doped diamond Anti‐inflammatories |