Synthesis and Anti-inflammatory Activity of a Novel Series of 9,10-Dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-one Derivatives |
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| Authors: | LIU Xiao-ping WANG Ying LAN Hui-yu SONG Ai-hua TSIM Karl Wah-keung DONG Tina Ting-xia HU Chun |
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| Institution: | LIU Xiao-ping1,WANG Ying2,LAN Hui-yu2,SONG Ai-hua1,TSIM Karl Wah-keung3,DONG Tina Ting-xia3 , HU Chun1 1.Department of Organic Chemistry,School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,P.R.China,2.Tianjin Key Laboratory of Chemistry , Analysis of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,3.Department of Biology,The Hong Kong University of Science , Technology,Clear Water Bay,Kowloon,Hong Kong |
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| Abstract: | Flavonoids exhibit a wide range of biological activities including anti-inflammatory activity,while some 1,3-benzoxazine derivatives show anti-inflammatory activity.In order to explore the novel anti-inflammatory agents,based on the principles of bioisosterism and hybridization,ten novel chromeno8,7-e]1,3]oxazin-4-ones were synthesized and characterized with IR,1H NMR,MS and elemental analyses.The anti-inflammatory activities of the target compounds were evaluated via the croton oil-induced ear oedema tes... |
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| Keywords: | Anti-inflammatory activity Heterocycle Flavone Chromeno[8 7-e][1 3]oxazin-4-one |
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