Enantioselective Palladium‐Catalyzed Insertion of α‐Aryl‐α‐diazoacetates into the OH Bonds of Phenols |
| |
| Authors: | Xiu‐Lan Xie Prof Shou‐Fei Zhu Jun‐Xia Guo Yan Cai Prof Qi‐Lin Zhou |
| |
| Institution: | 1. State Key Laboratory and Institute of Elemento‐organic Chemistry, Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn;2. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) |
| |
| Abstract: | A palladium‐catalyzed asymmetric O? H insertion reaction was developed. Palladium complexes with chiral spiro bisoxazoline ligands promoted the insertion of α‐aryl‐α‐diazoacetates into the O? H bond of phenols with high yield and excellent enantioselectivity under mild reaction conditions. This palladium‐catalyzed asymmetric O? H insertion reaction provided an efficient and highly enantioselective method for the preparation of synthetically useful optically active α‐aryl‐α‐aryloxyacetates. |
| |
| Keywords: | α ‐aryl‐α ‐aryloxyacetates asymmetric catalysis bisoxazoline ligands carbenes palladium |
|
