Double Transfer of Chirality in Organocopper‐Mediated bis(Alkylating) Cycloisomerization of Enediynes |
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| Authors: | Dr Damien Campolo Dr Tanzeel Arif Cyril Borie Dr Dominique Mouysset Dr Nicolas Vanthuyne Dr Jean‐Valère Naubron Prof Michèle P Bertrand Dr Malek Nechab |
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| Institution: | 1. Aix‐Marseille Université, CNRS, Institut de Chimie Radicalaire UMR7273, 13390 Marseille (France);2. Aix‐Marseille Université, CNRS, Institut des Sciences Moléculaires de Marseille UMR 7313, 13390 Marseille (France);3. Spectropole, Fédération de Chimie Marseille (France) |
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| Abstract: | An original synthesis of chiral benzofulvenes triggered by organocopper reagents is reported. These enantiopure products are available through a highly chemo‐, regio‐, diastereo‐, and enantioselective bis(alkylating) cycloisomerization process. A double chirality transfer (central‐to‐axial‐to‐central) is observed. |
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| Keywords: | alkynes carbocycles chirality copper cycloisomerization |
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