| Interactions with ATP, DNA Cleavage and Anti-tumor Activities of Complexes with Anions [Mo（V）O2（O2CeH4）2]^3-, [Mo（Ⅴ）0.5W（Ⅵ）0.5O2（O2C6H4）2]^2.5- and [W（Ⅵ）O2（O2C6H4）2]^2- |
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| 引用本文： | 鲁晓明,姜凌,毛希安,叶朝晖,卢景芬,崔景荣.Interactions with ATP, DNA Cleavage and Anti-tumor Activities of Complexes with Anions [Mo（V）O2（O2CeH4）2]^3-, [Mo（Ⅴ）0.5W（Ⅵ）0.5O2（O2C6H4）2]^2.5- and [W（Ⅵ）O2（O2C6H4）2]^2-[J].中国化学,2005,23(6):781-785. |
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| 作者姓名： | 鲁晓明 姜凌 毛希安 叶朝晖 卢景芬 崔景荣 |
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| 作者单位： | [1]DepartmentofChemistry,CapitalNormalUniversity,Beijing100037,China／／WuhanInstituteofPhysicsandMathematics,ChineseAcademyofSciences,Wuhan,Hubei430071,China [2]WuhanInstituteofPhysicsandMathematics,ChineseAcademyofSciences,Wuhan,Hubei430071,China [3]NationalResearchLaboratoryofNaturalandBiomimeticDrugs,SchoolofPharmaceuticalScience,PerkinUniversity,Beijing100083,China |
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| 摘 要： | (NH3CH2CH2NH2)3Mo(Ⅴ)O2(O2C6H4)2] (1), (NH3CH2CH2NH2)2.5Mo(Ⅴ)o.sW(Ⅵ)o.502(O2C6H4)2] (2) and(NH3CH2CH2NH2)2VC(Ⅵ)O2(O2C6H4)2] (3) were synthesized, structurally characterized by X-ray diffraction analysis, and studied on their interactions with ATP, their DNA cleavage activities and antitumor properties. The redox state of molybdenum was not changed on going from crystal to aqueous solutions in complexes 1 and 2, while tungsten underwent reduction from W(VI) to W(V) in complexes 2 and 3. ATP promoted the oxidation of both molybdenum and tungsten from M(Ⅴ) to M(Ⅵ) and the hydrolysis of catecholate ligands in solution consisting of ATP and the complexes. Complex 1 possesses fairly good activity to DNA cleavage and against tumor S180 in mice, and is more effective than the control drug cyclophosphamide under the identical conditions. However, complexes 2 and 3 exhibited marginal effectiveness. The effectiveness of anti-tumor of the complexes was related positively to their DNA cleavage activities and their hydrolysis of catecholate ligands.
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| 关 键 词： | DNA 抗肿瘤活性 药物 [Mo（V）O2（O2CeH4）2]^3- 阴离子 钼 晶体结构 |
Interactions with ATP,DNA Cleavage and Anti‐tumor Activities of Complexes with Anions [Mo(V)O2(O2C6H4)2]3‐, [Mo(V)0.5W(VI)0.5O2(O2C6H4)2]2.5‐ and [W(VI)O2(O2C6H4)2]2‐ |
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| Lu Xiao‐Ming,Jiang Ling,Mao Xi‐An,Ye Chao‐Hui,Lu Jing‐Fen,Cui Jing‐Rong.Interactions with ATP,DNA Cleavage and Anti‐tumor Activities of Complexes with Anions [Mo(V)O2(O2C6H4)2]3‐, [Mo(V)0.5W(VI)0.5O2(O2C6H4)2]2.5‐ and [W(VI)O2(O2C6H4)2]2‐[J].Chinese Journal of Chemistry,2005,23(6):781-785. |
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| Authors: | Lu Xiao‐Ming Jiang Ling Mao Xi‐An Ye Chao‐Hui Lu Jing‐Fen Cui Jing‐Rong |
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| Abstract: | (NH3CH2CH2NH2)3Mo(V)O2(O2C6H4)2] ( 1 ), (NH3CH2CH2NH2)2.5Mo(V)0.5W(VI)0.5O2(O2C6H4)2] ( 2 ) and (NH3CH2CH2NH2)2W(VI)O2(O2C6H4)2] ( 3 ) were synthesized, structurally characterized by X‐ray diffraction analysis, and studied on their interactions with ATP, their DNA cleavage activities and antitumor properties. The redox state of molybdenum was not changed on going from crystal to aqueous solutions in complexes 1 and 2 , while tungsten underwent reduction from W(VI) to W(V) in complexes 2 and 3 . ATP promoted the oxidation of both molybdenum and tungsten from M(V) to M(VI) and the hydrolysis of catecholate ligands in solution consisting of ATP and the complexes. Complex 1 possesses fairly good activity to DNA cleavage and against tumor S180 in mice, and is more effective than the control drug cyclophosphamide under the identical conditions. However, complexes 2 and 3 exhibited marginal effectiveness. The effectiveness of anti‐tumor of the complexes was related positively to their DNA cleavage activities and their hydrolysis of catecholate ligands. |
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| Keywords: | cis‐dioxo‐molybdenum(V) cis‐dioxo‐molybdo(V)tungsten(VI) cis‐dioxo‐tungsten(VI) catechol adenosine triphosphate DNA cleavage antitumor |
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