A Naphthalimide-Based Fluorescent Probe for the Detection and Imaging of Mercury Ions in Living Cells |
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| Authors: | Shaoyu Lei Xia Meng Dr Lizhen Wang Prof Jianhua Zhou Prof Dawei Qin Prof Hongdong Duan |
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| Institution: | 1. School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Ji'nan, Shandong Province, 250353 China;2. Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250103 Shandong Province, China |
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| Abstract: | The selective and efficient monitoring of mercury (Hg2+) contamination found in the environment and ecosystem has been carried out. Thus, a new 1,8-naphthalimide-based fluorescent probe NADP for the detection of Hg2+ based on a fluorescence enhancement strategy has been designed and synthesized. The NADP probe can detect Hg2+ with high selectivity and sensitivity and a low detection limit of 13 nm . The detection mechanism was based on a Hg2+-triggered deprotection reaction, resulting in a dramatic change in fluorescence from colorless to green at physiological pH. Most importantly, biological investigation has shown that the NADP probe can be successfully applied to the monitoring of Hg2+ in living cells and zebrafish with low cytotoxicity. |
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| Keywords: | cell imaging deprotection reactions mercury ions naphthalimide fluorescent probes |
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