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An optical resolution of racemic organophosphorous esters by phosphotriesterase-catalyzing hydrolysis |
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| Authors: | Ohuchi Shokichi Nakamura Hiroyuki Sligiura Hlroto Narita Mltsuaki Sode Koji |
| Institution: | (1) Department of Biotechnology, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, 184 Koganei, Tokyo, Japan |
| Abstract: | Conclusion We have shown that PTE chiral recognition is limited to organophosphorous esters having the chiral center on the phosphorous atoms, which is attacked with nucleophile, not having the chiral center on the other atoms of the leaving group. Therefore, PTE can be utilized for the synthesis of their chiral organophosphorous esters. |
| Keywords: | Index Entries" target="_blank">Index Entries Phosphotriesterase stereospecific reaction organophosphorous insecticide phosphotriesters kinetic optical resolution |
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