Antimicrobial activity of secondary metabolites from Streptomyces sp. K15, an endophyte in Houttuynia cordata Thunb |
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| Authors: | Huabao Chen Chunping Yang Tao Ke Miaomiao Zhou Zhaojun Li Min Zhang |
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| Affiliation: | 1. College of Life Science;2. Sichuan University, Chengdu 610064, P.R. China;3. College of Agronomy, Sichuan Agricultural University, Wenjiang District, Chengdu 611130, P.R. China |
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| Abstract: | We isolated Streptomyces sp. K15 from the root tissue of Houttuynia cordata Thunb and found that some of its secondary metabolites exhibited significant antimicrobial activity against Botrytis cinerea. Moreover, we separated, purified and identified the major active ingredient to be 2-pyrrol formic acid by using silica gel column chromatography, high-performance liquid chromatography and NMR analysis of the spectral data. 2-Pyrrol formic acid critically inhibited the growth of some phytopathogenic bacteria. Therefore, it has potential value in agricultural applications. |
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| Keywords: | endophyte secondary metabolites Streptomyces albolongus 2-pyrrol formic acid antimicrobial activity |
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