A new naphthoquinone and other antibacterial constituents from the roots of Xanthium sibiricum |
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Authors: | Wen-Hao Chen Wen-Jie Liu Yan Wang Xiao-Ping Song |
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Institution: | Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, P. R. China |
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Abstract: | Reinvestigating the chemical constituents of the roots of Xanthium sibiricum led to the isolation of a new naphthoquinone (1), together with 13 known compounds (2–14). Their structures were elucidated by using spectroscopic analyses, including HR-ESI-MS, 1D and 2D NMR, and by comparing their NMR data with those of related compounds. Compound 1 showed moderate antibacterial activity against Escherichia coli, Bacillus subtilis, Micrococcus tetragenus and Staphylococcus aureus, while 6 and 12 showed stronger antibacterial activity than the positive control ciprofloxacin against E. coli, with minimum inhibitory concentration values of 0.17 and 0.35 μg/mL, respectively. |
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Keywords: | Xanthium sibiricum Patr compositae chemical constituents antibacterial activity |
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