Sassarandainol: a new neolignan and anti-inflammatory constituents from the stem of Sassafras randaiense |
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| Authors: | Ya-Ling Hou Hsun-Shuo Chang Hui-Chun Wang Sheng-Yang Wang Tze-Ying Chen Chu-Hung Lin |
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| Institution: | 1. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC;2. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC;3. Department of Forestry, National Chung Hsing University, Taichung 402, Taiwan, ROC;4. National Ilan University, Ilan 260, Taiwan, ROC;5. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC |
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| Abstract: | A new neolignan, (R)-( ? )-sassarandainol (1), together with 10 known compounds (2–11), was isolated from the stem of Sassafras randaiense. The structures were determined by spectroscopic techniques. Among these isolates, γ-tocopherol (5), subamolide B (7) and β-sitosterone (9) exhibited moderate iNOS inhibitory activity on nitrite production induced (%) value of 30.51, 28.68 and 16.96, respectively. |
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| Keywords: | Sassafras randaiense Lauraceae stem neolignan (R)-( ? )-sassarandainol anti-inflammatory activity |
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