Chemical composition and anti-inflammatory activities of the essential oils from Acacia mearnsii de Wild |
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| Authors: | Opeyemi N Avoseh Kayode Aremu Benedicta N Nkeh-Chungag Sandile P Songca Samuel O Oluwafemi |
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| Institution: | 1. Department of Chemistry, Faculty of Science and Agriculture, University of Fort Hare, Alice, South Africa;2. Department of Zoology, Faculty of Science, Engineering and Technology, Walter Sisulu University, Mthatha, South Africa;3. Department of Chemistry, School of Applied and Environmental Sciences, Walter Sisulu University, Mthatha, South Africa;4. Department of Chemistry, Cape-Peninsula University of Technology, P.O. Box 652, Capetown 8000, South Africa |
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| Abstract: | The volatile oils of the leaves and the stem bark of Acacia mearnsii de Wild obtained by hydro-distillation were analysed by gas chromatography–mass spectrometry. A total of 20, 38, 29 and 38 components accounted for 93.8%, 92.1%, 78.5% and 90.9% of the total oils of the fresh, dry leaves and fresh, dry stem bark, respectively. The major components of the oil were octadecyl alcohol (25.5%) and phytol (10.5%); cis-verbenol (29.5%); phytol (10.1%) and phytol (23.4%) for the fresh leaves, dried leaves, fresh stem, dry stem bark, respectively. Oral administration of essential oils at a dose of 2% showed significant (p < 0.05) anti-inflammatory properties in the albumin-induced test model in rats. Oils from the fresh leaves and dry stems inhibited inflammation beyond 4 h post treatment. The potent anti-inflammatory activity of essential oils of A. mearnsii hereby confirmed its traditional use in treating various inflammatory diseases. |
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| Keywords: | Acacia mearnsii inflammation essential oils cis-verbenol phytol egg albumin-induced oedema |
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