Ultra-performance liquid chromatography coupled with high-resolution quadrupole time-of-flight mass spectrometry analysis of the impact of bran-processing on the chemical profile of Radix Paeoniae Alba (Baishao) |
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| Authors: | Zhiyong Zheng Xin Wu Baochang Cai |
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| Institution: | 1. Department of Pharmacy, Wenzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Wenzhou, P.R. China;2. Research Center of TCM Processing Technology, Zhejiang Chinese Medical University, Hangzhou, P.R. China |
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| Abstract: | In this study, a rapid and versatile ultra-performance liquid chromatography coupled with high-resolution quadrupole time-of-flight mass spectrometry-based chemical profiling approach was applied to evaluate chemical constitution of crude and processed Radix Paeoniae Alba (RPA) samples. A total of 44 compounds were identified, among which the contents of 9 compounds in processed samples were obviously decreased and 8 compounds were increased. Furthermore, compound 28 was not found in RPA sample after stir-frying with wheat bran. The proposed method provided a chemical basis for exploring the processed mechanism of herbal medicine. |
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| Keywords: | ultra-performance liquid chromatography coupled with high-resolution quadrupole time-of-flight mass spectrometry processed mechanism Radix Paeoniae Alba chemical profile |
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