| S-烷基异硫脲盐作为硫醇替代物经环氧开环反应合成β-羟基硫化物 |
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| 引用本文： | 朱继让,李日东,葛泽梅,程铁明,李润涛.S-烷基异硫脲盐作为硫醇替代物经环氧开环反应合成β-羟基硫化物[J].中国化学,2009,27(4):791-796. |
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| 作者姓名： | 朱继让 李日东 葛泽梅 程铁明 李润涛 |
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| 作者单位： | 天然及仿生药物国家重点实验室, 药学院 北京大学 北京100191 |
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| 摘 要： | S-烷基异硫脲盐作为一种无毒、无味、易于制备的硫醇替代物，在碱性水介质中、室温下与多种环氧化合物发生环氧开环反应，区域选择性、高收率地合成了一系列β-羟基硫化物。
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| 关 键 词： | 环氧化合物的硫解 硫醇替代物 S-烷基异硫脲盐 β-羟基硫化物 环境友好 |
| 收稿时间： | 2008-10-25 |
| 修稿时间： | 2008-11-24 |
Synthesis of β‐Hydroxy Sulfides via Thiolysis of Epoxides Using S‐Alkylisothiouronium Salts as Thiol Equivalents in Basic Aqueous Medium |
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| Jirang ZHU,Ridong LI,Zemei GE,Tieming CHENG,Runtao LI.Synthesis of β‐Hydroxy Sulfides via Thiolysis of Epoxides Using S‐Alkylisothiouronium Salts as Thiol Equivalents in Basic Aqueous Medium[J].Chinese Journal of Chemistry,2009,27(4):791-796. |
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| Authors: | Jirang ZHU Ridong LI Zemei GE Tieming CHENG Runtao LI |
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| Institution: | 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;2. Tel.: 0086‐10‐82801504;3. Fax: 0086‐10‐82716956 |
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| Abstract: | S‐Alkylisothiouronium salt as a nontoxic, odorless and simply operational alternative of thiol was reacted with different kinds of epoxides in basic aqueous medium at room temperature affording the β‐hydroxy sulfides with high regioselectivity in excellent yields. |
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| Keywords: | thiolysis of epoxide thiol equivalent S‐alkylisothiouronium salt β‐hydroxy sulfide environmental friendliness |
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