| Enantiomeric Resolution on L—Carnitine Selective Polymers Prepared by Molecular Imprinting |
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| 引用本文： | XiaoTaoLI GuangGuangJIANG 等.Enantiomeric Resolution on L—Carnitine Selective Polymers Prepared by Molecular Imprinting[J].中国化学快报,2002,13(2):157-158. |
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| 作者姓名： | XiaoTaoLI GuangGuangJIANG |
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| 作者单位： | [1]DepartmentofChemistry,YuquanCampusofZhejiangUniversity,Hangzhou310027 [2]DepartmentofChemicalEngineering,YuquanCampusofZhejiangUniversity,Hangzhou310027 |
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| 基金项目： | Research supported by The Analysis & Test Fund of Zhejiang Province. |
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| 摘 要： | L-carnitine selective polymers were prepared by molecular imprinting using methacrylic acid as the functional monomer. The acid function of the monomer is expected to form hydrogen bond and ionic interactions with the amine function of the target molecule L-carnitine.The imprinted polymers were used as stationary phases in high-performance liquid chromatography (HPLC). It was shown that L-carnitine imprinted polymer exhibited a higher affinity to its template molecule,while the non-imprinted polymer had no affinity to the compounds tested. Racemic carnitine hydrochloride was efficiently resolved on the L-carnitine imprinted polymer, and the separation factor is 1.9.
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| 关 键 词： | 左旋－肉毒碱 制备 选择性聚合物 氢氯化物 对映体分解 |
Enantiomeric Resolution on L-Carnitine Selective Polymers Prepared by Molecular Imprinting |
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| Xiao Tao LI,Guang Guang JIANG,Yue Hua SHI,Zhu De XU.Enantiomeric Resolution on L-Carnitine Selective Polymers Prepared by Molecular Imprinting[J].Chinese Chemical Letters,2002,13(2):157-158. |
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| Authors: | Xiao Tao LI Guang Guang JIANG Yue Hua SHI Zhu De XU |
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| Abstract: | L-carnitine selective polymers were prepared by molecular imprinting using methacrylic acid as the functional monomer. The acid function of the monomer is expected to form hydrogen bond and ionic interactions with the amine function of the target molecule L-carnitine. The imprinted polymers were used as stationary phases in high-performance liquid chromatography (HPLC). It was shown that L-carnitine imprinted polymer exhibited a higher affinity to its template molecule, while the non-imprinted polymer had no affinity to the compounds tested. Racemic carnitine hydrochloride was efficiently resolved on the L-carnitine imprinted polymer, and the separation factor is 1.9. |
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| Keywords: | L-carnitine racemic carnitine hydrochloride molecular imprinting polymer HPLC |
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