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Advances of responsive deep eutectic solvents and application in extraction and separation of bioactive compounds
Authors:Mengying Zhang  Ze Zhang  Zarmina Gul  Mengfei Tian  Junling Wang  Kaili Zheng  Chunjian Zhao  Chunying Li
Institution:1. College of Chemistry, Chemical Engineering, and Resource Utilization, Key Laboratory of Forest Plant Ecology, Ministry of Education, Engineering Research Center of Forest Bio-Preparation, Ministry of Education, Heilongjiang Provincial Key Laboratory of Ecological Utilization of Forestry-based Active Substances, Northeast Forestry University, Harbin, P. R. China

These authors contributed equally to this work.;2. College of Chemistry, Chemical Engineering, and Resource Utilization, Key Laboratory of Forest Plant Ecology, Ministry of Education, Engineering Research Center of Forest Bio-Preparation, Ministry of Education, Heilongjiang Provincial Key Laboratory of Ecological Utilization of Forestry-based Active Substances, Northeast Forestry University, Harbin, P. R. China

Abstract:In recent years, it has been found that changing ambient conditions (CO2/N2, temperature, pH) can trigger a switchable phase transition of deep eutectic solvents, and such solvents are known as responsive deep eutectic solvents. In this work, we present the development history, properties, and preparation of responsive deep eutectic solvents, followed by the application of responsive deep eutectic solvents in the extraction and separation of bioactive compounds are presented. Importantly, the mechanism of responsive deep eutectic solvents in the extraction of bioactive compounds is discussed. Finally, the challenges and prospects of responsive deep eutectic solvents in the extraction and separation of bioactive compounds are proposed. Responsive deep eutectic solvents are considered green and efficient solvents. Some methods for extraction and separation of bioactive compounds by responsive deep eutectic solvents can increase the possibility of recycling the deep eutectic solvents, and provide higher efficiency in the extraction and separation field. It is hoped that this will provide a reference for the green and sustainable extraction and separation of various bioactive compounds.
Keywords:bioactive compounds  extraction  green solvents  responsive deep eutectic solvents
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