Reconstruction of Abdominal Wall Defect with Composite Scaffold of 3D Printed ADM/PLA in a Rat Model |
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| Authors: | Zhicheng Song Dongchao Yang Qingxi Hu Yiming Wang Haiguang Zhang Wenpei Dong Jianjun Yang Yan Gu |
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| Institution: | 1. General Surgery, Huadong Hospital Affiliated to Fudan University, 221 Yan 'an West Road, Jing 'an District, Shanghai, Shanghai, 200040 China;2. Rapid Manufacturing Engineering Center, Shanghai University, 99 Shangda Road, Baoshan District, Shanghai, Shanghai, 200444 China;3. Administrative office, Tenth People's Hospital of Tongji University, 301 Yanchang Zhong Lu, Jing 'an District, Shanghai, Shanghai, 200072 China |
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| Abstract: | Abdominal wall defects are a frequently occurring condition in surgical practice. The most important are material structure and biocompatibility. In this study, polylactic acid (PLA) mesh composited with a 3D printing of acellular dermal matrix (ADM) material is used to repair abdominal wall defects. The results show that the adhesion score of ADM/PLA composite scaffolds is smaller than PLA meshes. Immunohistochemical assessment reveals that the ADM/PLA composite scaffold can effectively reduce the inflammatory response at the contact surface between the meshes and the abdominal organs. And the ADM/PLA composite scaffold can effectively reduce the expression levels of the inflammation-related factors IL-6 and IL-10. In addition, the ADM/PLA composite scaffold repair is rich in the expression levels of tissue regeneration-related factors vascular endothelial growth factor and transforming growth factor β. Thus, ADM/PLA composite scaffolds can effectively reduce surrounding inflammation to effectively promote the repair of abdominal wall defects. |
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| Keywords: | 3D print abdominal wall defects acellular dermal matrix regeneration |
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