Click Inspired Synthesis of 1,2,3‐Triazole‐linked 1,3,4‐Oxadiazole Glycoconjugates |
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Abstract: | The glycoconjugation of biologically privileged 1,3,4‐oxadiazole scaffold is described via Cu(I)‐catalyzed azide–alkyne cycloaddition. A series of glycosyl alkynes 1b – i , obtained from various commercial sugars, were treated with azide functionalized 1,3,4‐oxadiazole using click chemistry to access triazole‐linked glycosylated 1,3,4‐oxadiazoles 10b – i in good yields. The structure of the developed glycoconjugates has been ascertained by extensive spectroscopic analysis (1H &13C NMR, IR, and MS). |
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