Computer-assisted structure manipulation : Studies in the biosynthesis of natural products |
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| Authors: | Tomas H Varkony Dennis H Smith Carl Djerassi |
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| Institution: | Contribution from the Departments of Chemistry and Genetics, Stanford University, Stanford, CA 94305, U.S.A. |
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| Abstract: | A computer program (“REACT”) that simulates chemical reactions by manipulating representations of structures has been utilized to study biochemical reactions. Biosynthetically plausible sterol side chains were generated and the number of plausible isomeric sterols were calculated. Possible label distributions in structures resulting from the biochemical conversion of a humulene precursor to some known fungal metabolites were followed by studying different biochemical pathways. |
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