| 若干3d过渡金属的甲氨喋呤配合物 |
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| 引用本文： | 陆小海,杨维达.若干3d过渡金属的甲氨喋呤配合物[J].应用化学,1989,6(5):11-15. |
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| 作者姓名： | 陆小海 杨维达 |
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| 作者单位： | 华东师范大学化学系，华东师范大学化学系 上海 上海医科大学药学院，上海 |
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| 摘 要： | 本文制得了甲氨喋呤与钒、锰、铁、钴、镍、铜和锌的配合物,除铁为氧桥双核型外,其余均为1:1单核配合物。通过热重、红外、磁化率、电子顺磁共振(对铜和钒酰)和Mossbauer谱(对铁)的表征,对它们的可能结构进行了讨论。
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| 关 键 词： | 甲氨喋呤 抗癌配体 过渡金属配合物 |
| 收稿时间： | 1988-11-22 |
COMPLEXES OF AMETHOPTERIN WITH SOME 3d TRANSITION METALS |
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| Lu Xiaohai,Yang Weida.COMPLEXES OF AMETHOPTERIN WITH SOME 3d TRANSITION METALS[J].Chinese Journal of Applied Chemistry,1989,6(5):11-15. |
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| Authors: | Lu Xiaohai Yang Weida |
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| Institution: | Lu Xiaohai,Yang Weida Department of Chemistry,East China Normal University,Shanghai |
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| Abstract: | Using the widely accepted combination-chemotherapeutic antitumor drug amethopterin(abbreviated mtxH_2) as ligand, seven complexes with the composition of VO(mtx). 5H_2O,Mn(mtx).5H_2O,(Femtx)_2O.10H_2O, Co(mtx).5~1/_2H_2O, Ni(mtx).61~/_2H_2O, Cu(mtx).4H~2O, and Zn (mtx).4H_2O, were prepared. The structures of the complexes were characterized and discussed by the thermogravi-metric, infrared, magnetic susceptibility, Mossbauer (for ferric complex) and electron para-magnetic resonance (for cupric and vanadyl complexes) measurements. |
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| Keywords: | Amethopterin Antitumor ligand Transition metal complexes |
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