| Mechanical properties of double-stranded DNA biofilm with Gaussian distribution简 |
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| 作者姓名： | Heng-Song Tang Wei-Lie Meng Neng-Hui Zhang |
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| 基金项目： | supported by the National Natural Science Foundation of China(11272193 and 10872121);the Shanghai Leading Academic Discipline Project(S30106) |
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| 摘 要： | In microcantilever-based label-free biodetection technologies, deflection changes induced by adsorptions of double-stranded DNA （dsDNA） molecules on Au-layer surface are greatly affected by the mechanical, thermal and electrical properties of DNA biofilm. In this paper, the elastic properties of dsDNA biofilm are studied. First, the Parsegian＇s empirical potential based on a mesoscopic liq- uid crystal theory is employed to describe the interaction energy among coarse-grained DNA cylinders. Then, con- sidering a Gaussian distribution of DNA interaxial distance, the thought experiment method is used to derive an analyti- cal expression for Young＇s modulus of DNA biofilm with a stochastic packing pattern for the first time. Results show that Young＇s modulus of DNA biofilm is on the order of 10 MPa. These findings could provide a simple and effective method to evaluate the mechanical properties of soft biofilm on snbstrate.
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| 关 键 词： | 双链DNA 机械性能 高斯分布 生物膜 生物检测技术 杨氏模量 相互作用能 分子吸附 |
Mechanical properties of double-stranded DNA biofilm with Gaussian distribution |
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| Heng-Song Tang,Wei-Lie Meng,Neng-Hui Zhang.Mechanical properties of double-stranded DNA biofilm with Gaussian distribution[J].Acta Mechanica Sinica,2014,30(1):15-19. |
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| Authors: | Heng-Song Tang Wei-Lie Meng Neng-Hui Zhang |
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| Institution: | 1. Shanghai Key Laboratory of Mechanics in Energy Engineering, Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University, 200072, Shanghai, China
2. Department of Mechanics, College of Sciences, Shanghai University, 200444, Shanghai, China
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| Abstract: | In microcantilever-based label-free biodetection technologies, deflection changes induced by adsorptions of double-stranded DNA (dsDNA) molecules on Au-layer surface are greatly affected by the mechanical, thermal and electrical properties of DNA biofilm. In this paper, the elastic properties of dsDNA biofilm are studied. First, the Parsegian’s empirical potential based on a mesoscopic liquid crystal theory is employed to describe the interaction energy among coarse-grained DNA cylinders. Then, considering a Gaussian distribution of DNA interaxial distance, the thought experiment method is used to derive an analytical expression for Young’s modulus of DNA biofilm with a stochastic packing pattern for the first time. Results show that Young’s modulus of DNA biofilm is on the order of 10MPa. These findings could provide a simple and effective method to evaluate the mechanical properties of soft biofilm on substrate. ![src=]() |
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| Keywords: | Double-stranded DNA Biofilm Elastic modu-lus Cylinder model Gaussian distribution |
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