| 多环百部生物碱Stemonamine的全合成 |
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| 引用本文： | 陈志华,涂永强,张书宇,张辅民.多环百部生物碱Stemonamine的全合成[J].中国科学:化学,2011(3):474-478. |
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| 作者姓名： | 陈志华 涂永强 张书宇 张辅民 |
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| 作者单位： | 功能有机分子化学国家重点实验室兰州大学化学化工学院; |
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| 基金项目： | 国家自然科学基金(20732002,20921120404,20972059,21072085); 教育部“111”计划; 科技部“973”项目(2010CB833203)的资助 |
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| 摘 要： | 以新颖的环氧醇串联Semipinacol重排/Schmidt反应为关键步骤,设计发展了高效构筑含有氮杂季碳中心的5,5,7]三环骨架1的方法.本文从关键中间体1出发,设计了关键的酮酯缩合反应构筑D环的方法,经过7步转化,高效、高选择性地完成了蔓生百部碱Stemonamine的全合成.
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| 关 键 词： | 串联反应 全合成 蔓生百部碱 |
An efficient total synthesis of Stemonamine |
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| CHEN ZhiHua,TU YongQiang,ZHANG ShuYu & ZHANG FuMin State Key Laboratory of Applied Organic Chemistry.An efficient total synthesis of Stemonamine[J].Scientia Sinica Chimica,2011(3):474-478. |
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| Authors: | CHEN ZhiHua TU YongQiang ZHANG ShuYu & ZHANG FuMin State Key Laboratory of Applied Organic Chemistry |
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| Institution: | CHEN ZhiHua,TU YongQiang,ZHANG ShuYu & ZHANG FuMin State Key Laboratory of Applied Organic Chemistry,Department of Chemistry,Lanzhou University,Lanzhou 730000,China |
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| Abstract: | A short and efficient approach to the Stemona alkaloids has been developed. The representative members, Stemonamine, has been synthesized from the known key intermediate 1 in 7 steps and 47.3% overall yield featured by a novel ketone-ester condensation to forge the spirolactone ring. |
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| Keywords: | tandem reaction total synthesis Stemonamine |
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