(S)-citramalic acid,a useful chiral synthon for the synthesis of 15-deoxy-16(S)-hydroxy-16-methylprostaglandins |
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| Authors: | Yoshinori Fujimoto JS Yadav Charles J Sih |
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| Institution: | School of Pharmacy, University of Wisconsin Madison, Wisconsin U.S.A. |
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| Abstract: | (S)-Citramalic acid, a readily available microbial metabolite has been efficiently transformed into (2S)-2-methyl-2-hydroxy-1-hexanol (), an important chiral synthon for the synthesis of 15-deoxy-16(S)-hydroxy-16-methylprostaglandins. |
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