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Prediction of interactiveness between small molecules and enzymes by combining gene ontology and compound similarity
Authors:Lei Chen  Ziliang Qian  Kaiyan Fen  Yudong Cai
Institution:1. Shanghai Key Laboratory of Trustworthy Computing, East China Normal University, Shanghai 200062, People's Republic of China;2. Centre for Computational Systems Biology, Fudan University, Shanghai 200433, People's Republic of China;3. Department of Combinatorics and Geometry CAS‐MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, People's Republic of China;4. Division of Imaging Science, Medical School, Stopford Building, The University of Manchester, ManchesterM13 9PT, United Kingdom;5. Institute of Systems Biology, Shanghai University, Shanghai 200444, People's Republic of China
Abstract:
Keywords:molecule‐enzyme couple  compound similarity  functional domain composition  gene ontology  blast  metabolic pathway  Nearest neighbor algorithm (NNA)  simple majority voting system
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