A fast,highly selective and sensitive dansyl-based fluorescent sensor for copper (II) ions and its imaging application in living cells |
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| Authors: | Ming Zhou Xiaobo Wang Kunzhu Huang Yuzhao Huang Shou Hu Wenbin Zeng |
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| Institution: | 1. Xiangya School of Pharmaceutical Sciences, Central South University, 172 Tongzipo Road, Changsha 410013, PR China;2. Xiangya Hospital, Central South University, Changsha 410078, PR China;3. Department of Nuclear Medicine, Henan Provincial People''s Hospital and People''s Hospital of Zhengzhou University, Henan 450003, PR China;4. School of Pharmaceutical Sciences, Changsha Medical University, Changsha 410219, PR China |
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| Abstract: | Since the copper ions (Cu2+) play a fatal role in many foundational physiological processes, it is important to develop a simple, highly sensitive and selective sensor for Cu2+ detection in living systems. Herein, an intramolecular charge transfer (ICT) and dansyl-based fluorescent chemosensor 1 was designed, synthesized and characterized for the sensitive and selective quantification of Cu2+. It exhibited remarkable fluorescence quenching upon addition of Cu2+ over other selected metal ions, attributed to the complex formation between 1 and Cu2+ with the association constant 6.7 × 105 M?1. The sensor 1 showed a fast and linear response towards Cu2+ in the concentration range from 0 to 12.5 × 10?6 mol L?1 with the detection limit of 2.5 × 10?7 mol L?1. This detection could be carried out in a wide pH range of 5.0–14. Furthermore, sensor 1 can be used for detecting Cu2+ in living cells. |
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| Keywords: | Fluorescent sensor Copper (II) ions Dansyl |
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