Antibacterial Constituents from Isodon Excisoides |
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| Authors: | Zhi‐An He Guang‐Zhou Lu Lin‐Lin Zhu Yong‐Xue Wang Fu‐Lin Yan Ji‐Xia Zhang |
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| Affiliation: | 1. Department of Medical Laboratory, Xinxiang Medical University, Xinxiang 453003, P. R. China;2. Pharmacy College, Xinxiang Medical University, Xinxiang 453003, P. R. China |
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| Abstract: | ![]()
Two new ent‐kaurane diterpenoids, taihangexcisoidesin C (1) and its acetonide, taihangexcisoidesin D (2), along with 9 known compounds were isolated from the leaves of Isodon excisoides. The structures of the new compounds were elucidated using 1D and 2D NMR spectroscopy analysis. Compounds 3‐6 and 8‐9 were tested for their antibacterial activity against Escherichia coli, Staphylococcus aureus, S. epidermidis and S. saprophyticus. Compound 6 showed inhibitory effects on Staphylococcus aureus, S. epidermidis and S. saprophyticus MIC values 32, 16 and 16 μg/mL, respectively. All of the compounds didn't show effects on Escherichia coli (MIC > 10 mg/mL). |
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| Keywords: | Isodon excisoides Ent‐kaurane diterpenoid Taihangexcisoidesin C and D Antibacterial activity |
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