Application of bromoacetate‐substituted β‐CD‐bonded silica particles as chiral stationary phase for HPLC |
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| Authors: | Sennappan K Thamarai Chelvi E L Yong Yinhan Gong |
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| Institution: | 1. Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;2. Tropical Marine Science Institute, National University of Singapore, Singapore |
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| Abstract: | Bromoacetate‐substituted 3‐(2‐O‐β‐cyclodextrin)‐2‐hydroxypropoxy]propylsilyl‐appended silica particles (BACD‐HPS), an important and useful synthetic intermediate for preparation of novel types of macrocycles‐capped β‐CD‐bonded silica particles including crown ether/cyclam/calix4]arene‐capped β‐CD‐bonded silica particles, have been prepared and used as chiral stationary phase for HPLC. This synthetic stationary phase is characterized by means of elemental analysis. For the first time, the chromatographic behavior of BACD‐HPS was systematically evaluated with several disubstituted benzenes and some chiral drug compounds under both normal and RP conditions in HPLC. The results show that BACD‐HPS has excellent selectivity for the separation of aromatic positional isomers and chiral isomers of some drug compounds when used as stationary phase in HPLC. |
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| Keywords: | β ‐CD Chiral separation Chiral stationary phase HPLC Macrocycle |
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