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Syntheses of thallusin analogues and their algal morphogenesis-inducing activities |
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| Authors: | Hirofumi Yamamoto Yuichi Takagi Naoto Yamasaki Tadashi Mitsuyama Yusuke Kasai Hiroshi Imagawa Yutaro Kinoshita Naohiro Oka Masanori Hiraoka |
| Affiliation: | 1. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan;2. Usa Marine Biological Institute, Kochi University 194 Inoshiri, Usa, Tosa, Kochi 781-1164, Japan;3. Graduate School of Technology, Industrial and Social Sciences, Department of Bioscience and Bioindustry, The University of Tokushima, Minamijosanjima 2-1, Tokushima 770-0814, Japan |
| Abstract: | Thallusin is the only known natural product that induces cell differentiation followed by formation of a thallus during the growth of green macroalgae such as Monostroma and Ulva. Herein, various thallusin analogues based on the terpen skeleton were synthesized to study the structure?activity relationships of thallusin. The potency of the synthetic analogues was investigated in an experimental assay, which demonstrated that the 19-methyl group in thallusin is essential for potent morphogenesis-inducing activity. |
| Keywords: | Structure?activity relationship Thallusin Marine algae Synthesis Tandem cyclization |
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