A novel fluorescent probe for formaldehyde based-on monomer-excimer conversion and its imaging in live cells |
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| Authors: | Baichuan Han Jin Sun Kai Chen Zhiyong Chen Minhua Huang Zhenzhong Gao Xianfeng Hou |
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| Institution: | 1. College of Materials & Energy, South China Agricultural University, Guangzhou, 510642, China;2. Zhongshan Collaborative Innovation Center of National Analytical Center of China, Zhongshan, 528476, China |
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| Abstract: | A novel fluorescent probe was developed for formaldehyde, which can be synthesized by one-step Buchwald–Hartwig reaction. When hydrazino-group of probe reacted with formaldehyde, hydrophobic reaction product aggregates into nanoparticles and results in the blue fluorescence due to the monomer-excimer effect. With enough sensitivity, high selectivity, good stability in physiological pH range and excellent biocompatibility, this probe can image formaldehyde in living cells. |
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| Keywords: | Fluorescent probe Formaldehyde Monomer-excimer conversion Bio-imaging |
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