| 叶酸修饰的具有靶向功能的Mn_3O_4造影剂的制备及其在核磁共振成像中的应用 |
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| 引用本文： | 杨昕仪,汤才志,周治国,杨仕平.叶酸修饰的具有靶向功能的Mn_3O_4造影剂的制备及其在核磁共振成像中的应用[J].中国科学:化学,2014(4):639-645. |
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| 作者姓名： | 杨昕仪 汤才志 周治国 杨仕平 |
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| 作者单位： | 资源化学省部共建教育部重点实验室,稀土功能材料上海市重点实验室,上海师范大学,上海200234 |
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| 基金项目： | 教育部创新团队(IRT1269);国家自然科学基金(21271130);上海市浦江人才计划项目(13PJ1406600)的资助 |
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| 摘 要： | 通过高温热解的方法制备出Mn3O4纳米粒子,再利用正硅酸四乙酯(TEOS)包硅改善其水溶性和稳定性,通过加入3-氨基丙基三乙氧基硅烷(APTES)使纳米粒子表面接入大量氨基,最后再连接增加磁性纳米粒子生物相容性的有机分子聚乙二醇(PEG)和靶向分子叶酸(FA),得到Mn3O4靶向造影剂.体外实验表明,该造影剂具有低的细胞毒性,并对宫颈癌细胞具有较好的磁共振增强成像效果以及主动靶向作用.
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| 关 键 词： | MnO 纳米粒子 磁成像 靶向 |
Folate-conjugated Mn304@SiO2 core-shell nanoparticles for targeted magnetic resonance imaging |
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| YANG XinYi,TANG CaiZhi,ZHOU ZhiGuo,YANG ShiPing.Folate-conjugated Mn304@SiO2 core-shell nanoparticles for targeted magnetic resonance imaging[J].Scientia Sinica Chimica,2014(4):639-645. |
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| Authors: | YANG XinYi TANG CaiZhi ZHOU ZhiGuo YANG ShiPing |
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| Institution: | The Key Laboratory of Resource Chemistry of Ministry of Education ＆ Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, China |
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| Abstract: | The rnonodisperse silica-coated manganese oxide nanoparticles （NPs） were synthesized via a thermal decomposition approach and were aminated through silanization. The amine-functionalized core-shell NPs enabled the covalent conjugation of organic hydrophilic PEG and folate （FA） onto their surfaces. The formed Mn304@SiO2- PEG-FA core-shell nanocomposites are water-dispersible, stable, and biocompatible. Furthermore, we demonstrate that Mn3Oa@SiO2-PEG -FA NPs as a T1 contrast agent display effective targeting ability, and lower toxicity in vitro, enabling them to be developed as multimodel nanoplatform for long-term targeted imaging. |
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| Keywords: | Mn3O4 nanoparticles MRI targeting |
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