| 比值光谱一阶导数法测定复方磺胺甲唑片中磺胺甲唑含量 |
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| 引用本文： | 孙增先,李瑞真,李永溟,王奎兴,张骞峰,周金玉.比值光谱一阶导数法测定复方磺胺甲唑片中磺胺甲唑含量[J].光谱学与光谱分析,2001,21(5):713-715. |
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| 作者姓名： | 孙增先 李瑞真 李永溟 王奎兴 张骞峰 周金玉 |
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| 作者单位： | 江苏省连云港市第一人民医院, |
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| 摘 要： | 本文应用比值光谱一阶导数法测定复方磺胺甲唑片剂中磺胺甲唑含量,依据磺胺甲唑比值导数光谱用峰零法在251nm处测定其含量,比值光谱一阶导数值与浓度(1～15μg@mL-1)线性关系良好,能有效消除甲氧苄啶的干扰,样品测定结果与药典方法比较没有显著差异(P＞0.05).
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| 关 键 词： | 比值光谱一阶导数 磺胺甲恶唑 甲氧苄啶 复方磺胺甲恶唑片 含量测定 抗菌消炎药物 |
| 文章编号： | 1000-0593(2001)05-0713-03 |
| 修稿时间： | 2000年1月10日 |
Determination of Sulfamethoxazole in Compound Sulfamethoxazole Tablet by First Derivative Ratio Spectrometry |
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| Z Sun,R Li,Y Li,K Wang,Q Zhang,J Zhou.Determination of Sulfamethoxazole in Compound Sulfamethoxazole Tablet by First Derivative Ratio Spectrometry[J].Spectroscopy and Spectral Analysis,2001,21(5):713-715. |
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| Authors: | Z Sun R Li Y Li K Wang Q Zhang J Zhou |
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| Institution: | No. 1 Hospital of Lianyungang, Jiangsu, Lianyungang 222002. |
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| Abstract: | The first derivative ratio spectrometry is used for the determination of sulfamethoxazole in compound sulfamethoxazole tablet. According to the first derivative ratio spectrum of sulfamethoxazole, peak-zero method is applied for the determination at 251 nm. There is a good linear correlation between the first derivative ratio spectrum value and concentration (1-15 micrograms.mL-1) for the method that can eliminate the disturbance of trimethoprim, and no difference while comparing the method with pharmacopoeia method (P > 0.05). |
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| Keywords: | First derivative ratio spectrum Sulfamethoxazole Trimethoprim |
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