醋酸纤维素衍生物的合成及包衣性质

用苯酐、四氢苯酐和甲基四氢苯酐对醋酸纤维素进行修饰,对醋酸纤维素邻苯二甲酸酯(CAP)、醋酸纤维素四氢邻苯二甲酸酯(CATH)和醋酸纤维素甲基四氢邻苯二甲酸酯(CAMT)的性质如酸值、膜透湿性、抗张强度、黏度和玻璃化转变温度进行了初步探讨,并选用盐酸青藤碱为模型药物进行包衣片剂的体外释放实验.结果表明,两类高分子材料的成膜性能良好,符合药剂学薄膜包衣材料的有关要求.包衣片的体外释放实验表明,CAMT和CATH作为薄膜材料在纯化水中释放药物的速度比醋酸纤维素薄膜材料释放药物的速度明显减慢.CAMT和CATH可以用作长效释药的包衣材料.

Synthesis of Cellulose Acetate Derivatives and Their Coating Properties

Phthalic anhydride, tetrahydrophthalic anhydride and methyhetrahydrophthalic anhydride were used to modify cellulose acetate. The properties such as acid values, membrane permeability, tensile strength, viscosity and glass transition temperature of cellulose acetate phthalate （CAP）, cellulose acetate tetrahydrophthalate （CATH） and cellulose acetate methyl tetrahydrophthalate（CAMT） were preliminarily investigated. At the same time, in vitro release experiments were carried out to evaluate the property of sinomenine tablets coated with CAP, CATH and CAMT. Results show that the two kinds of macromolecular materials had good film-forming ability and met the requirements for pharmaceutical film coatings. The tab lets coated with CAMT and CATH had a slower drug release rate in purified water than that coated with cellulose acetate. And CAMT and CATH may be used as coating materials for long term drug delivery.