| Biotransformation of 14-Deacetoxy-13-oxo sinenxan A by Ginkgo Cell Cultures |
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| 作者姓名： | Jun Gui DAI Meng ZHANG Min YE Wei Hua ZHU Ji Yu GUO Xiao Tian LIANG* Institute of Materia Medica Chinese Academy of Medical Science & Peking Union Medical College Beijing |
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| 作者单位： | Jun Gui DAI，Meng ZHANG，Min YE，Wei Hua ZHU，Ji Yu GUO，Xiao Tian LIANG* Institute of Materia Medica，Chinese Academy of Medical Science & Peking Union Medical College，Beijing 100050 |
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| 摘 要： | Sinenxan A, 2a, 5a, 10b,14b-tetraacetoxy-4(20),11-taxadiene, is a taxoid isolated from the callus cultures of Taxus spp. in high yield (ca. 1~2% of dry weight)1,2. The rich resources and its taxane-skeleton vest it valuable potential for the semisynthesis of paclitaxel or other structurally related bioactive compounds, such as 搒econd -generation?taxoid anticancer agents and taxane-based multidrug resistant anticancer agents3-5. Many remarkable studies on its structural modification by chemi…
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Biotransformation of 14-Deacetoxy-13-oxo sinenxan A by Ginkgo Cell Cultures |
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| Jun Gui DAI,Meng ZHANG,Min YE,Wei Hua ZHU,Ji Yu GUO,Xiao Tian LIANG* Institute of Materia Medica,Chinese Academy of Medical Science & Peking Union Medical College,Beijing .Biotransformation of 14-Deacetoxy-13-oxo sinenxan A by Ginkgo Cell Cultures[J].Chinese Chemical Letters,2003,14(8). |
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| Authors: | Jun Gui DAI Meng ZHANG Min Ye Wei Hua ZHU Ji Yu GUO Xiao Tian LIANG |
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| Abstract: | Deacetoxy-13-oxo sinenxan A (1) was converted to 9a-hydroxy-13-oxo-2a, 5a, 10b-triacetoxy-4(20),11-taxadiene (2) and 10b-hydroxy-13-oxo-2a,5a,9a-triacetoxy- 4(20), 11- taxadiene (3) by Ginkgo cell suspension cultures in 45% and 15% yields, respectively. |
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| Keywords: | Biotransformation taxane cell suspension cultures Ginkgo biloba L |
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