Highly Enantioselective Direct Asymmetric Aldol Reaction Catalyzed by 4,5‐Methano‐L‐proline |
| |
Authors: | Yukun Zhang Jun Zhu Na Yu Han Yu |
| |
Institution: | 1. School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China;2. College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing, Zhejiang 314001, China |
| |
Abstract: | The 4,5‐methano‐L‐proline was used as chiral organocatalysts in direct asymmetric aldol reactions. Under the optimal conditions, excellent enantioselectivities (up to 99% ee) were obtained with high chemical yields (up to 95%) for a series of aldehydes using only 5 mol% catalyst loading. To show the practicality of the method, the reaction was tested at a large scale. The reaction was complete in 16 h, and the aldol product was obtained in 86% yield and 93% ee. |
| |
Keywords: | asymmetric organocatalysis direct asymmetric aldol reaction 4 5‐methano‐L‐proline |
|
|