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Highly Enantioselective Intramolecular Morita‐Baylis‐Hillman Reaction Catalyzed by Mannose‐Based Thiourea‐phosphine |
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| Authors: | Weihong Yang Kui Yuan Hongliang Song Feng Sha Xinyan Wu |
| Institution: | Key Laboratory for Advanced Material and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China |
| Abstract: | The saccharide‐based chiral bifunctional thiourea‐phosphines were developed as chiral organocatalysts for the intramolecular Morita‐Baylis‐Hillman reaction of ω‐formyl‐enones. With only 2 mol% of thiourea‐phosphine catalyst 3c , chiral functionalized cyclohexenes were achieved under mild reaction conditions with excellent yields and enantioselectivities. |
| Keywords: | allylic alcohol bifunctional thiourea‐phosphine chiral squaramide enantioselective organocatalysis Morita‐Baylis‐Hillman reaction |