| 3-芳胺甲烯基-6-烷基(芳基)-5,6-二氢-2H-吡喃-2,4-二酮的合成及其杀菌活性的研究 |
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| 引用本文： | 王有名,李正名,李佳凤,李树正,张素华.3-芳胺甲烯基-6-烷基(芳基)-5,6-二氢-2H-吡喃-2,4-二酮的合成及其杀菌活性的研究[J].高等学校化学学报,1999,20(10):1559-1563. |
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| 作者姓名： | 王有名 李正名 李佳凤 李树正 张素华 |
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| 作者单位： | 南开大学元素有机化学研究所, 天津 300071 |
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| 摘 要： | 以5,6-二氢-6-烷基(芳基)-2H-吡喃-2,4-二酮(1)、芳胺(2)和原甲酸三乙酯进行缩合反应,合成了20个3-芳胺甲烯基-6-烷基(芳基)-5,6-二氢-2H-吡喃-2,4-二酮(3).由于分子内氢键的形成,化合物3由一对构象异构体4和5组成.生物活性初步测定结果表明,这些化合物均有一定的杀菌活性.
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| 关 键 词： | 缩合反应 分子内氢键 构象异构体 杀菌活性 |
| 收稿时间： | 1999-01-04 |
| 修稿时间： | 1999年1月4日 |
Synthesis and Fungicidal Activity of 3-Anilinomethylene-5,6-dihydro-6-alkyl (aryl)-2H-pyran-2,4-diones |
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| WANG You-ming,LI Zheng-Ming,LI Jia-Feng,LI Shu-Zheng,ZHANG Su-Hua.Synthesis and Fungicidal Activity of 3-Anilinomethylene-5,6-dihydro-6-alkyl (aryl)-2H-pyran-2,4-diones[J].Chemical Research In Chinese Universities,1999,20(10):1559-1563. |
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| Authors: | WANG You-ming LI Zheng-Ming LI Jia-Feng LI Shu-Zheng ZHANG Su-Hua |
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| Institution: | Institute of Elemento Organic Chemistry, Nankai University, Tianjin 300071, China |
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| Abstract: | Anilinomethylene 6 alkyl(aryl) 5,6 dihydro 2H pyran 2,4 diones(3) were prepared by the condensation reaction of 6 alkyl(aryl) 5,6 dihydro 2H pyran 2,4 diones(1), substituted anilines(2) and ethyl orthoformate. A pair of conformational isomers 4 and 5 exist in products 3 due to the formation of the intramolecular hydrogen bond. Compound 3 was tested in vitro against many fungi such as P. Zeae, C. Arachidicala, P. Piricola, A. Solani, B. Cinerae, S. Sclerotiorum, H. Oryzae, etc . The bioassay results show that they have some fungicidal activity. |
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| Keywords: | Condensation reaction Intra molecular hydrogen bond Conformational isomers Fungicidal activity |
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